Changzhou Sunsanta Chemical Co.,Ltd
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Tel: 86-519-83980506
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City: changzhou
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CAS NO.2353-33-5
High purity/Top quality Decitabine /5-aza-2'-deoxycytidine intermediates
Product Name 5-Aza-2'-deoxycytidine
Molecular Formula C8H12N4O4
Molecular Weight 228.2053
CAS Registry Number 2353-33-5
EINECS 219-089-4
Density 1.9g/cm3
Melting point 200°C (dec.)
Boiling point 485.8°C at 760 mmHg
Refractive index 1.779
Flash point 247.6°C
Vapour Pressur 1.78E-11mmHg at 25°
SUNSANTA
We are one of the leading exporters in China in the fields of active pharma
ingredients including oncology drug, prostaglandin, anti-HIV drug, cardiovascular
drug, diabetes drug, anti-inflammatory drug, urinary system drug, cosmetics peptide
and intermediate, dyestuff & pigment and kinds of package materials.
We specialize in synthesis of novel organic compounds, process development
and manufacturing of pharmaceutical and fine organic chemicals from gram to kilogram quantity.
We supply
1.in very competitive price;
2.Quality Guaranteed;
3.Fast Delivery;
4.Payment:L/C;D/P;TT;;Paypal.
5.On-time shipment and pre-shipment product quality safeguards.
Specification
High purity/Top quality Decitabine /5-aza-2'-deoxycytidine intermediates
| Decitabine | CAS 2353-33-5 | Brand: SUNSANTA |
| MW:228.2 | MSDS: Avaiable | |
| MF: C8H12N4O4 | Sample: Avaiable | |
| Category: API | Min order: 10grams | |
| Quality standard: USP | Place of Origin:China | |
| Usage: | Cyproterone acetate has antagonistic properties towards the 5-Aza-2'-Deoxycytidine, has been reported to cause phosphorylation inhibition of 2'-deoxycytidine in certain cells and the incorporation of 2'-deoxycytidine into DNA. Experiments have shown that this compound induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits Dnmt (DNA methyltransferase). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2'-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2. | |
| Applications | Pharmaceutical raw materials A Dnmt inhibitor | |